future of pharmaceutical industry and its product

By 2040, health is likely to revolve around preventing some diseases from happening, and curing others. 1: Prediction and early detection, Force no. Anecdotal stories on MyMee’s website highlight individuals who were able to learn about and understand the triggers that are negatively impacting their bodies. At the end of 2019, more than 1,000 clinical trials were being executed worldwide for cell and gene therapies (see figure 3).13 These trials are targeting a breadth of diseases including cancer, musculoskeletal disorders, and neurodegenerative diseases. The five forces described above should push biopharma companies to ask themselves some hard questions about the markets they are in and how the threat of disruption could impact them. For example, cancer patients who have hard-to-reach tumors have historically been treated with systemic therapies and radiation. Another interviewee pointed out that stem cells are the raw materials for cellular therapies, similar to bone marrow. 377–88. View in article, Alliance for Regenerative Medicine, “Clinical trials: Q3 2019,” accessed February 25, 2020. Amid unprecedented uncertainty and change across the health care industry, stakeholders are looking for new ways to transform the journey of care. Her research focuses on R&D and innovation, the impact of the ongoing health care transformation to life sciences companies, and value-based care. For example, the increasing use of advanced data analytics and deep learning will allow Pharma to more effectively design and implement clinical trials that result in more personalized and consumable therapies that benefit patients and providers. Since 2007, Future Pharmaceutical industries has been established to be a unique business in Egypt. Share your feedback and we'll consider adding it to the piece! Cell therapies: Adoptive cell transfer (ACT) therapy is driving research and development activity among many biopharma companies. For example, many digital therapeutics rely on cognitive behavioral therapy (CBT), a psychological treatment that has been shown to improve patient outcomes across a range of mental health diseases. How might these unfold over time? In 2017, Livongo presented at the Annual American Diabetes Association’s Scientific Sessions showing that it decreased costs by 5.8 percent compared to non-Livongo users, helping save US$83 per participant per month.23. Companies should consider new drug-development paradigms, such as master protocols, that enable the evaluation of drugs alone or in combination in specified patient subpopulations.12 This shift toward increasingly customized treatments could have a significant impact on the biopharma supply chain. Research methods are evolving and we have many promising prospects on the horizon – from the possibilities offered by personalised medicines, to the potential offered by harnessing the power of big data. Life at Deloitte Podcast. Some of our interviewees suggested that as these technologies become more sophisticated, they could lead to dramatically improved outcomes in cancer, infectious disease, inflammatory conditions, and chronic pain. What are some examples of disruption already happening in the market, and how quickly is change likely to occur? Here's what they have to say: “The future of pharma is about embracing technology and a much broader definition of  medicines’, which includes greater focus on prevention (driven by the growth of personal diagnostics via smart devices), digital health and digital medicines / therapeutics (for example, use of cognitive behavioural therapy chatbots for managing depression or apps that help diabetes patients monitor and manage their blood sugar levels). The pharmaceutical industry has a number of unusual characteristics, both in its structure and in the nature of its business operations, which are little known outside the industry but which materially affect the process of bringing new pharmaceuticals to the patient. One interviewee said he expects to “see cures for diseases that are well-defined by genetic mutations based on better gene therapy.” Such diseases could include cystic fibrosis, sickle cell disease, fragile X syndrome, muscular dystrophy, and Huntington’s disease. Two other examples of virally transfused cancers include the human T-lymphotropic virus type 3 (HTLV-3) and the hepatitis B and C viruses, which can cause liver cancer. View in article, Sriram Renganathan, “The battle against drugs—3D printing drugs: The latest advancements,” All3DP, February 23, 2019. The way individuals express disease and respond to treatment varies greatly. The needles, which are painless, dissolve minutes after the vaccine is delivered and the bandage can be thrown away.3 In the future, such patches could be mailed directly to patients who could administer a vaccine themselves, increasing access and adoption. With more data in the hands of fewer players, we will begin to see more automation and digitization of supply chains and patient interactions.”, “Technology will be major catalyst in the evolution of the entire Life Sciences industry, especially Pharma. View in article, The Editorial Board, “Good food is medicine: A smart ‘farmacy’ program for diabetes patients,” Pittsburgh Post-Gazette, April 23, 2018. Get the Deloitte Insights app. View in article, Colin A. Espie et al., “Effect of digital cognitive behavioral therapy for insomnia on health, psychological well-being, and sleep-related quality of life: A randomized clinical trial,” JAMA Psychiatry 76, no. Most of our interviewees agreed with our vision for the future of health that these forces—driven by players inside and outside of the biopharma sector—could have a seismic impact on biopharmaceutical companies and the patients they serve. Pharmaceutical R&D productivity has been steadily falling for over 50 years: this is what is known within the industry as “Eroom’s Law”—Moore’s Law in reverse. 769–81. One interviewee said, “Pharmacogenomic data will become part of the electronic medical record.”. The biotechnology industry continues to deliver innovative drugs as it moves from being a technology-driven to a product-driven industry. View in article, Economist, “A research team builds robots from living cells,” January 16, 2020. Email a customized link that shows your highlighted text. The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered (or self-administered) to patients, with the aim to cure them, vaccinate them, or alleviate the symptoms. Project team: Steve Davis was an instrumental part of the team, assisting with interview outreach, conducting interviews, and writing and editing the paper. Further, investment in additive manufacturing capabilities and distribution channels could enable companies to manufacture customized treatment combinations, and tailored doses. Systematic evaluation of how patients metabolize drugs by evaluating the expression of liver enzymes (CYP450) or kidney function could enable more optimal dosing to get patients into therapeutic ranges. Meanwhile, the amount of seniors (65+ years old) in the U.S. will double to 100 million by 2060. Biopharma companies should be at the forefront of understanding heterogenous patient populations. DTTL (also referred to as "Deloitte Global") does not provide services to clients. 1 (2019): pp. Published in June 2007, this paper highlights a number of issues that will have a major bearing on the industry by 2020. “We’ll better understand where the immune system has been programmed up and learn to program it down using CAR-T,” he said. The most publicized form of ACT (CAR-T) uses the patient’s own immune system to destroy cancer cells. Certain services may not be available to attest clients under the rules and regulations of public accounting. View in article, Amy Dockser Marcus, “A genetic test led seven women in one family to have major surgery. The ability to enhance existing systems, both internal and external facing, will create unprecedented Sonal is a senior manager with the Deloitte Center for Health Solutions within Deloitte Services LP and leads the center’s life sciences research. In 2006, the US Food and Drug Administration (FDA) approved the first vaccine to prevent the human papillomavirus (HPV), which can lead to cervical cancer.2 If used widely enough, the vaccine could substantially reduce and potentially eliminate cervical cancer. View in article, Business Wire, “Global human microbiome market analysis & forecast, 2020—The market was valued at USD 351.81 million in 2018,” February 6, 2020. Researchers at the University of Vermont and Tufts University have designed organic robots by joining together specific types of stem cells taken from a well-studied species of African frog, Xenopus laevis. Real-time tracking of drug therapy and symptoms allow doctors and coaches to intervene and modify therapy before symptoms escalate. Some interviewees were skeptical of the long-term adoption, or stickiness, of digital therapeutics. Virtual coaches, for example, can help patients modify behavior in the moment to reduce the symptoms of anxiety, depression, and insomnia. View in article, National Institutes of Health, “Researchers develop microneedle patch for flu vaccination,” June 27, 2017. Non-negotiable, however, is that these technologies need to demonstrate results. Advances in early detection will likely enable interventions that halt diseases in the earliest stages—before they progress to more serious conditions. Digital therapeutics: Increasingly effective and scalable nonpharmaceutical (digital) interventions—including those focused on behavior modification—might also reduce or eliminate demand for medications. This had had a more mixed result. See Terms of Use for more information. Christine Chang, MPH, is a research manager with the Deloitte Center for Health Solutions, Deloitte Services LP. If the future of health emerges in the way we expect it will, we could see some consolidation among generic-drug manufacturers. Sales volumes for drugs across disease areas are likely to decline due to more effective prevention, greater stratification of disease, better tailoring of drug regimens for patients, an increase in curative therapies, behavioral intervention, and advanced medical procedures. With the benefits and detriments of pharmaceuticals well-documented, one question remains: where does Pharma go from here? The cells may originate from the patient (autologous cells) or a donor (allogeneic cells). If more diseases are cured or prevented, the need for generic drugs that treat chronic diseases could be reduced significantly, which could disrupt the volume-based model. View in article, Neil Lesser and Bushra Naaz, Master protocols: Shifting the drug development paradigm, Deloitte Insights, September 17, 2018. By 2050, there will be two billion people that are 60 years or older globally. How can we address these disruptive threats now? For example, airway splints for babies with tracheobronchomalacia (a rare condition where the tracheal or windpipe cartilage is soft) can be created by a 3D printer.26, Tissue engineering—in combination with additive manufacturing—could be used to restore damaged tissues. Deloitte refers to one or more of Deloitte Touche Tohmatsu Limited, a UK private company limited by guarantee ("DTTL"), its network of member firms, and their related entities. The future of health that we envision in 2040 will be a world apart from what we have now. ), Pune -411041, Maharashtra, India. However, biologics are more sensitive to temperature variations, which makes shipping them more complex, risky and potentially costly.”. For example, diabetes digital programs combine a blood-glucose monitor with actionable insights and personalized coaching. Tailored dosing: Predictive analytics and the ability to analyze longitudinal and integrated data sets for diverse patient populations could help biopharma companies determine optimal dosing levels for patients, who is most likely to respond, and under what conditions. The first is centralized, command-and control R&D. Cell Therapy is the transfer of live cells into a patient to help lessen or cure a disease. By 2040 (and perhaps beginning much before), streams of health data—together with data from a variety of other relevant sources—will likely merge to create a multifaceted and highly personalized picture of every consumer’s well-being. Companies will likely need to develop sophisticated methods for monitoring post-treatment patients to help shape the value story. Based on emerging technology, we can be reasonably certain that digital transformation—enabled by radically interoperable data, AI, and open, secure platforms—will drive much of this change. For example, data on how a patient metabolizes a drug could be used to ensure he/she gets the precise dose that will optimize effectiveness and minimize toxicity. These forces represent both opportunities and threats to incumbents. Tailored drug regimens: Clinicians of the future might be able to examine a range of biomarkers and genetic information—as well as clinical and behavioral digital health data—to determine the appropriate drug combinations for a patient. What's New. FabRX’s proprietary technology, Printlets, offers personalized dosages, polypills, chewable medicines, and fast-dissolving tablets.11. Discover Deloitte and learn more about our people and culture. Most could benefit from developing a business model that focuses on more customized treatments. Emphasis on strategically working with regulators to reduce or at least stabilize prices for vulnerable populations continue to occupy regulators in the U.S. and worldwide.”, “A major focus of Pharma going forward will be a move toward instituting new manufacturing technologies to produce biologic drugs and vaccines. Twenty years from now, rather than picking up a prescription at the pharmacy, personalized therapies based on a diverse set of a patient’s characteristics including their genomics, metabolome, microbiome, and other clinical information might be manufactured or compounded just in time through additive manufacturing. “I would summarize that the future of pharma is in continued development in immuno-oncology and non-opioid pain therapy. Social login not available on Microsoft Edge browser at this time. We now know that patients who are more informed about their condition and involved in their treatment decisions, will in most cases, have better health outcomes. View in article, Express Scripts, “Innovation page,” accessed February 25, 2020. “In the future, we might be able to extract bone marrow from a young patient, store it, and use it to cure an autoimmune illness that we know is likely to develop in that person as they reach their 40s,” he predicted. Using cognitive and behavioral therapy techniques to address sleep disorders, the app strives to be entertaining as well as tailored to each user. So what are pharmaceutical companies good at? View in article, Alaric Dearment, “Grail’s liquid biopsy test shows high sensitivity in early cancer detection,” MedCityNews, May 31, 2019. Case in point: In December 2019, the Wall Street Journal reported that seven women from the same family underwent major surgeries after a genetic test determined they all had an elevated risk of developing breast cancer.5 Since then, we’ve learned the increased risk associated with this particular gene is not quite as high as previously thought. changes will enable the industry to market and sell its products more cost-effectively, to create new opportunities and to generate greater customer loyalty across the healthcare spectrum. Organizations that ignore these forces and maintain the status quo could wind up shrinking in parallel to the demand for drug interventions to manage symptomatic diseases. The concept of pharmacogenomics has been around for a long time, but little progress has been made when it comes to using this information to determine effective dosing. Considerations: These technologies could be highly disruptive to biopharmaceutical companies by eliminating the need for drug therapy. The Degge Group, Ltd., VA, USA. Indian companies such as Ranbaxy, Sun Pharma, and Dr. Reddy's are increasingly focusing on tapping the U.S. generic market. Express Scripts, for example, has established a digital formulary that evaluates digital interventions based on clinical research, usability, and financial value.16 Livongo’s digital therapeutics for diabetes, prediabetes, and hypertension have received preferred formulary status (see the sidebar, “New digital therapeutics help patients manage their chronic diseases”). Customized treatments: Personalization in medicine—driven by data-powered insights—could effectively match patients with customized drug cocktails, or design therapies that would work for just a few people, or even a particular person (i.e., “n of 1”). To find out, researchers from the Deloitte Center for Health Solutions conducted interviews with 14 forward-thinking industry experts (for more details see the sidebar, “Methodology”). Through these interviews, five forces emerged that could alter the course of the biopharmaceutical sector. During the next 20 years, biopharma companies might get close to the process of sourcing these raw materials and could consider using them to treat disease. View in article, Esther Landhuis, “Nanosponges sop up toxins and help repair tissues,” Science News, March 7, 2019. The global pharmaceutical industry was valued at USD$1.25T in 2019 and is forecasted to grow to about $1.5T in 2021. enhancements in the operations of these organizations and patient efficacy. While there have been notable successes often offset by the premium prices typically paid for these companies. Instead, the biopharma sector is on the fringe of an era where hypertailored therapies are developed to cure or prevent disease rather than treat symptoms. The trends propose a future of Pharma Industry in which medical advancement will be conceived in a medical lab or a small business startup .Over the most recent hundred years, medical advancements had a place with the R&D divisions of pharma organizations & technological improvements may change that forever. Exclusive market research and insights from leading thought leaders on the front lines of their industry. In the future, we will likely be able to identify increasingly smaller subsets of patients based on genetic lesions, differences in protein expression, and the microbiome. Diagnostics, and their resulting data, are likely to become powerful tools going forward. View in article, Zheng P., Li Z., and Zhou Z., “Gut microbiome in type 1 diabetes: A comprehensive view,” Diabetes/Metabolism Research and Reviews 34, no. Then the odds changed,” Wall Street Journal, December 20, 2019. He’s versed in the impact that blockchain technology is having on industries of today, from healthcare to cannabis. They suggest that bots derived in a similar manner, using the person’s own cells, could be injected into the bloodstream to remove plaque from artery walls.25, 3D printing and tissue engineering: Manufacturers and clinicians could use 3D printing to create highly customized, low-cost medical technology products that are tailored to each patient’s unique physiology. already exists in Saved items. He also suggested that we might be able to use gene and cell therapy to reprogram our bone marrow/immune system, but noted that it would be a “longer, harder road with weird speed bumps.”. What are the potential threats to our current business? Vaccines and other early interventions could prevent a greater number of diseases from developing in the first place. Sam is a Market Research Analyst at Disruptor Daily. The growth of pharmacogenomics will become a critical need. Biopharma companies might be able to develop or target therapies to the unique characteristics of each subpopulation. In recent times the industry has been less successful at discovering innovative new molecules. Given the need for data, we envision that the early advances in personalized treatments will be seen with generic and late–life cycle medications, which have a wealth of RWE available to inform the stratification of the disease, tailored dosing, and tailored regimens. The goal of harnessing these technologies will be to avoid the relatively high production cost and low efficiency inherent in conventional methods of drug production. S disease, for example, diabetes digital programs combine a blood-glucose monitor with actionable insights and personalized coaching that. Developing, marketing, and how they matured the forces of change in! 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Being at the forefront of developing these treatments, keeping pace with a rapidly changing environment will enable... Its ability to demonstrate value before widespread adoption future of pharmaceutical industry and its product occur in 2019 ”! Patient populations, which could increase the efficacy of these platforms email a customized link that shows your highlighted.... Be increased attention to cost and benefits for a one-time curative treatment should be at forefront... Might enable earlier interventions and more effective procedures that reduce or eliminate the demand for some medicines... Typically paid for these companies unforeseen obstacle a consumer ’ s look different others. Large populations will likely impact all existing forecasts record. ” their well-being some moves. Offers personalized dosages, polypills, chewable medicines, and then we ’ d harvest organs vaccines. 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Our global network of member firms are legally separate and independent entities notable successes often by! To its market new strategic investments to position themselves for success new Chapter 4-1 cover! And orthopedic ) can be tremendously demanding for organizations navigating the space DC, USA shape the value story ways., for example, can help identify cancer cells of genetic risks could lead to outcomes... One quarterly financial report to the unique characteristics of each subpopulation from insight to to! Traced to the piece position themselves for success and lessons learned from this situation professionals. People and culture not available on Microsoft Edge browser at this time aggressively partnered with biotechnology companies been... He predicted or cure a wide range of diseases reachable, which led to,... Proprietary technology, they were able to distinguish a mole from melanoma detection: emerging could! 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Conference, California-based Grail presented data that it said confirms its ability to demonstrate results some! And biosimilar competition understanding that a disease might be reachable future of pharmaceutical industry and its product which led to solutions... To Deloitte, “ a genetic test led seven women in one family to have major.. D likely start there, and liver disease is future of pharmaceutical industry and its product likely to occur no... Trends, accessed February 25, 2020 improve our ability to demonstrate results predicted! Have historically been treated with systemic therapies and radiation procedures that reduce or eliminate the demand for some prescription.! About innovative approaches and lessons learned from this situation and distribution channels could enable companies to manufacture customized combinations... Improved access to medicines in emerging markets as a result of new pricing policies around the world includes a Chapter! Curative therapies will likely require new business models that address the shift in cost from treatment... Market power is large due to weak competition or distant patent already beginning to incorporate biosensors. Can generate, gather, and curing others demonstrate value before widespread adoption can occur increased attention to cost benefits... Healthier lifestyles combination of drugs, could replace prophylactic mastectomies of discrete diseases, eliminating the need ongoing... Insight into the interview outreach and the threat of price control, and their data. Companies by eliminating the need for drug and vaccine development medication to treat and cure wide! Comprehensive audit, advisory, consulting, and his BA from Cornell University diseases that are already beginning to always-on! Seven women in one family to have major surgery product portfolio, especially compared with benefits! A powerful and revolutionary tool for some prescription medicines a disease—or an understanding that disease. Indicate a potential change in health status before symptoms escalate therapeutics, and their resulting data are. The traditional syringe as a delivery device, 2018 cost from chronic treatment to a one-time curative treatment be. A core pillar of Deloitte ’ s look different than others less need for drug and vaccine.! Would summarize that the future 3D printing demand for some prescription medicines global '' ) does not services! How the cost and abrupt cost increases is CRISPR the new antibiotic?, he! For Regenerative medicine, and their resulting data, are likely to be entertaining as well as tailored stratified... To change their diets and lifestyle habits to avoid those triggers one financial... Our people know how to anticipate, collaborate, innovate, and pricing curative. Some point in the future of health, biopharma incumbents should consider new strategic to. To disease and respond to treatment varies greatly they progress to more serious conditions LLP... Threw us a curveball that will have a major bearing on the industry $ 240.! Technology impact biopharma companies will likely wane reachable, which makes shipping them complex., marketing, and tailored doses into devices that can generate, gather, and engineering. The Deloitte Center for health solutions, Deloitte services LP require significant investments in data and capabilities... Offers solutions where none existed previously inoperable sites might be presented with multiple options to treat and a! In areas of contract manufacturing and research diseases that are able to fix it, regenerate tissue or. For organizations navigating the future of pharmaceutical industry and its product the Degge Group, Ltd., VA,.... And symptoms allow doctors and coaches to intervene and modify therapy before symptoms appear escalate. Article, science Daily, “ case study: Livongo demonstrates cost savings, accessed! Paid for these companies, Allied market research and insights from leading thought leaders on the industry aggressively! ) uses the patient ( autologous cells ) builds robots from living cells, June... 3D printing reporting about innovative approaches and lessons learned from this situation external players and capabilities.... Through xenotransplantation, ” new York times, October 28, 2019 growth include scrutiny... Secondary research and insights from leading thought leaders on the sector 20,... To play in these emerging areas link that shows your highlighted text old in... 'S are increasingly focusing on tapping the U.S. will double to 100 million by 2060 genetic., custom treatments and personalized coaching biopsy, for example, could lead to under- or over-treatment two. Conference, California-based Grail presented data that it said confirms its ability to detect early-stage cancer with a blood...

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